Speaker Details



Osaka University

Dr. Shizuo Akira is a Director and Professor of WPI Immunology Frontier Research Center, and also a Professor in the Institute for Microbial Diseases at Osaka University, Japan. He received his M.D. and Ph.D. from Osaka University. After two years of postdoctoral work in the Department of Immunology, University of California at Berkeley, he started to study IL-6 gene regulation and signaling at the Institute for Molecular and Cellular Biology, Osaka University, and cloned transcription factors, NF-IL6(C/EBP beta) and STAT3. He was a Professor in Department of Biochemistry, Hyogo College of Medicine from 1996 to 1999, where he became involved in Toll-like receptors research. By generating TLR family knockout mice, he identified ligands of many TLR members. He also demonstrated that the difference in signaling pathways among TLRs is due to selective usage of adaptor molecules such as MyD88 and TRIF. He demonstrated that pathogen-derived RNA is recognized by a cytoplasmic receptor family, besides TLRs, and clarified the molecular mechanism of antiviral response against RNA viruses. His current research interests are molecular mechanisms of innate immunity and inflammation, which are studied mainly by generating knockout mice.

Awards and Honors: 2004 Robert Koch Prize, 2006 William B. Coley Award for Distinguished Research in Basic Immunology, 2007 Imperial Prize and Japan Academy Prize, 2009 National Academy of Sciences of USA, Foreign Associate & Person of Cultural Merit, 2010 Keio International Medical Science Prize & Avery-Landsteiner Prize & EMBO Associate Member, The 2011 Canada Gairdner International Award, 2014 Member of the Japan Academy.

Symposium Faculty

Elçin Ünal

University of California, Berkeley

Ali Deniz Güler

University of Virginia

Yasemin Sancak

Washington University

Ömer Yılmaz

Massachusetts Institute of Technology

Joseph L. Goldstein

University of Texas

Michael S. Brown

University of Texas, Southwestern Medical Center

Linda Partridge

University College London

Bruce Spiegelman

Harvard Medical School

Ronald M. Evans

Salk Institute

Leslie Vosshall

The Rockefeller University

Michael Czech

University of Massachusetts Medical School

Jean Schaffer

Washington University

Gerald Shulman

Yale University

Shizuo Akira

Osaka University

Brenda Schulman

St. Jude Children's Research Hospital

Vamsi Mootha

Massachusetts General Hosptial

Peter Walter

University of California, San Francisco