Speaker Details



St. Jude Children's Research Hospital

Brenda Schulman’s lab studies how proteins and lipids are regulated by becoming covalently linked to the small protein ubiquitin or to structurally related ubiquitin-like proteins (UBLs). This is a widespread mechanism controlling timing, subcellular location, assembly, conformation, and activity of thousands of different human proteins and macromolecules. Defects in ubiquitin and UBL pathways have been associated with numerous diseases, including cancers, neurodegenerative disorders, and viral infections. Thus, understanding mechanisms underlying regulation by ubiquitin and UBLs is of broad importance for understanding signaling pathways and targeting them in diseases. The Schulman lab is recognized for illuminating the mechanisms of ubiquitin and UBL ligation, and for using a distinctive in vitro biochemical reconstitution approach to identify novel in vivo regulatory pathways.

Dr. Schulman received her Ph.D. from M.I.T. in 1996, was a postdoctoral fellow at MGH Cancer Center and at Memorial Sloan-Kettering Cancer Center, and began her faculty appointment at St. Jude Children’s Research Hospital in 2001. She is an Investigator of the Howard Hughes Medical Institute, and the Joseph Simone Chair in Basic Research at St. Jude. Schulman has been named a Pew Scholar in the Biomedical Sciences and a Beckman Young Investigator, and she received a Presidential Early Career Award for Scientists and Engineers. She was a joint winner of The Protein Society’s Dorothy Crowfoot Hodgkin Award, and was elected to the American Academy of Arts and Sciences in 2012 and the National Academy of Sciences in 2014, and was named a Vallee Visiting Professor in 2016.

Symposium Faculty

Elçin Ünal

University of California, Berkeley

Ali Deniz Güler

University of Virginia

Yasemin Sancak

Washington University

Ömer Yılmaz

Massachusetts Institute of Technology

Joseph L. Goldstein

University of Texas

Michael S. Brown

University of Texas, Southwestern Medical Center

Linda Partridge

University College London

Bruce Spiegelman

Harvard Medical School

Ronald M. Evans

Salk Institute

Leslie Vosshall

The Rockefeller University

Michael Czech

University of Massachusetts Medical School

Jean Schaffer

Washington University

Gerald Shulman

Yale University

Shizuo Akira

Osaka University

Brenda Schulman

St. Jude Children's Research Hospital

Vamsi Mootha

Massachusetts General Hosptial

Peter Walter

University of California, San Francisco